wb403WB403 (WB-403) is a novel and potent TGR5 activator with antidiabetic effects. It can improve glucose tolerance and decrease fasting blood glucose, postprandial blood glucose and HbA1cWB403 preserved the mass of pancreatic β-cells and normal distribution of α and β-cells. (A) H&E staining of pancreas from dbdb mice, and statistical result. Islets were sized by